The recommended single intravenous dose in adults and pediatric patients one month and older for a surgical procedure is 1.25 mg to 5 mg.Perhaps that is the point – that there is a “splinter of ice in the heart of a writer”, as Greene famously said, and “an icicle” in the heart of a spy – but it leaves us dissatisfied all the same.Visualization of Vessels, Blood Flow and Tissue Perfusion (2.5 mg/mL solution): The play’s programme quotes Yuri Modin, the KGB controller of the “Cambridge Five”, who says of Philby: “He never revealed his true self.” This play seems no closer to taking us to the heart of either man. In the melancholy closing image, he is a lone figure in his living room. Philby insists he has no regrets but his words are undercut by the information that he is virtually friendless in Moscow and overreliant on Rufa. “You can’t betray what you never belonged to,” he says.

Philby admits to betraying his father but justifies the lives lost as a result of his spying, insisting that he was never a double agent. The most fascinating element of their conversation is how espionage intersects with loyalty – towards family and friends. She has a few more lines later, but these are to fill in Philby’s backstory rather than bring her truly to life. Philby’s fourth wife, Rufa (Sara Crowe), is little more than a minor character in the first act, taking Greene’s coat and scurrying off to the kitchen. But there is too much exposition after this – “Then Macmillan cleared you,” Greene tells Philby “My book was published and you kindly wrote the foreword,” says Philby – and we don’t get beyond the weight of research to a more elemental face-off. The small talk in the first act is amusing enough – Philby tells Greene he takes holidays to Cuba and Czechoslovakia and still reads the Times every day. Backstory … Sara Crowe as Philby’s wife, Rufa.

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